CIROZA BILIARA PRIMITIVA \/ cirrhose biliaire primitive \/ primary biliary cirrhosis. Tip de c. de cauza necunoscuta, o serie de date sugerand o afectare a canalelor biliare medi-ata imunologic. Astfel, In 90%dincazurile de c. bPROBA au fost detectati In sange anticorpi antimitocondriali, care recunosc trei pana la cinci proteine din membrana mitocondriala interna. Totodata, In 80-90% din cazuri se constata o crestere a IgM serice si a *crioproteinelor, care constau In *complexe imune capabile sa activeze ‘complementul. Anatomopatologic se de- scriu, de obicei pentru studii, leziuni initiate de „colangita cro-nica distructiva ce se extind, afectand progresiv canalele bill-are si hepatodtele; concomitent se produc fibroza periportala ?i proliferarea tesutului conjunctiv, cu dezvoltarea In final a c. – micro- sau macronodulare. Boala evolueaza circa cinci ani, moartea survenind prin hemoragii digestive si insufidenta he- patica grava. Pe baze anatomopatologice au fost descrise trei forme de c. b. p.: *boala Hanot, *boala Hanot-Kiener si *boala Hanot-Rossle, ultima fiind considerate) In prezent o afectiune distincta (‘colangita difuza non-obliteranta). Exista o forma con- genitala de c. b. p., cu atrezie sau malformatie a cailor bi-liare intrahepatice: v. sindromReynolds. <\/p>\n","protected":false},"excerpt":{"rendered":"
CIROZA BILIARA PRIMITIVA \/ cirrhose biliaire primitive \/ primary biliary cirrhosis. Tip de c. de cauza necunoscuta, o serie de date sugerand o afectare a canalelor biliare medi-ata imunologic. Astfel, In 90%dincazurile de c. bPROBA au fost detectati In sange anticorpi antimitocondriali, care recunosc trei pana la cinci proteine din membrana mitocondriala interna. Totodata, In […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[3],"tags":[],"class_list":{"0":"post-4055","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-dictionar-medical"},"_links":{"self":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/posts\/4055","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/comments?post=4055"}],"version-history":[{"count":0,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/posts\/4055\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/media?parent=4055"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/categories?post=4055"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/tags?post=4055"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}