{"id":14709,"date":"2014-08-20T21:01:05","date_gmt":"2014-08-20T18:01:05","guid":{"rendered":"http:\/\/www.sursamedicala.ro\/blog\/\/receptor-insulinic\/"},"modified":"2014-08-20T21:01:05","modified_gmt":"2014-08-20T18:01:05","slug":"receptor-insulinic","status":"publish","type":"post","link":"https:\/\/www.sursamedicala.ro\/blog\/receptor-insulinic\/","title":{"rendered":"RECEPTOR INSULINIC"},"content":{"rendered":"<p>RECEPTOR INSULINIC \/ recepteur insulinique \/ insuline re- ceptor. Glicoproteina cu M^de 350 kDa, alcatuita din doua sub-unitati a de 125-135 kDa si doua subunitati p de 90-95 kDa, legate prin punti disulfurice. Se gaseste Tn membranele plas-matice ale majoritatii tipurilor celulare din organism, dar Tndeosebi la nivelul tesutului hepatic, muscular si adipos. Mecanismul de transmitere a informatiei spedfice la nivelul r. i. nu este clarificat: probabil, tirozinkinaza stimulate prin autofosforilarea subunitatii par. mediaza majoritatea actiunilor insulinei. R. i. sunt implicati Tn perturbarile tolerantei la glucoza si ale sensi-bilitatii la insulina (&#8216;insulinorezistenta), ca urmare a unor mutatii ale r. Unele dintre acestea altereaza capacitatea de legare a insulinei, iar altele &#8211; stabilitatea, semnalizarea sau reciclarea. Estimarea frecventei mutatiilor de la nivelul r. i. sugereaza fap-tul ca ele constituie o cauza rara de diabet. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>RECEPTOR INSULINIC \/ recepteur insulinique \/ insuline re- ceptor. Glicoproteina cu M^de 350 kDa, alcatuita din doua sub-unitati a de 125-135 kDa si doua subunitati p de 90-95 kDa, legate prin punti disulfurice. Se gaseste Tn membranele plas-matice ale majoritatii tipurilor celulare din organism, dar Tndeosebi la nivelul tesutului hepatic, muscular si adipos. Mecanismul de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"tdm_status":"","tdm_grid_status":"","footnotes":""},"categories":[3],"tags":[],"class_list":["post-14709","post","type-post","status-publish","format-standard","category-dictionar-medical"],"_links":{"self":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/posts\/14709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/comments?post=14709"}],"version-history":[{"count":0,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/posts\/14709\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/media?parent=14709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/categories?post=14709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sursamedicala.ro\/blog\/wp-json\/wp\/v2\/tags?post=14709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}